ブックタイトル2013ATCC

概要

2013ATCC

HorizonBRAF (V600E/+);EGFR (ΔE746-A750/+)遺伝子名カタログNo.親株名組織特記事項HD 200-002 hTERT-HME1 BreastEGFR (ΔE746-A750/+) HD 100-001 hTERT-HME1 BreastEGFR (ΔE746-A750/+) HD 101-010 MCF10A BreastEGFR (ΔE746-A750/+) HD 114-004 NCI-H838 LungEGFR (ΔE746-A750/+) HD 106-009 RKO ColonEGFR (ΔE746-A750/+);PIK3CA (H1047R/+)EGFR (ΔE746-A750/+);PIK3CA (H1047R/+)HD 200-001 hTERT-HME1 BreastHD 201-001 MCF10A BreastEGFR (I491M/+/+) HD 103-042 SW48 ColonDouble heterozygous knock-in of BRAF and EGFRactivating mutationsHeterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)Heterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)Heterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)Heterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)Double heterozygous knock-in of EGFR and PIK3CAactivating mutationsDouble heterozygous knock-in of EGFR and PIK3CAactivating mutationsHeterozygous knock-in of EGFR I491M mutation incis configuration with endogneous G719S mutationEGFR (L65V/+/+) HD 103-046 SW48 Colon Heterozygous knock-in of EGFR point mutation (L65V)ATCC・Horizon Discovery遺伝子変異細胞株カタログAPC123456789EGFR (L858R/+)HD 101-016MCF10ABreastEGFR (L858R/+)HD 114-005NCI-H838LungEGFR (L858R/+)HD 106-006RKOColonEGFR (L858R/+/+)HD 103-045SW48ColonEGFR (L861Q/+)HD 101-017MCF10ABreastEGFR (L861Q/+)HD 106-007RKOColonEGFR (S492R/+/+)HD 103-041SW48ColonEGFR (S492R/+/+)HD 103-044SW48ColonEGFR (T790M/+)HD 101-019MCF10ABreastEGFR (T790M/+)HD 106-005RKOColonTP53 (-/-); EGFR (ΔE746-A750/+)HD 101-029MCF10ABreastHeterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L861Q)Heterozygous knock-in of EGFR activating mutation(L861Q)Heterozygous knock-in of EGFR S492R mutation intrans configuration with endogneous G719S mutationHeterozygous knock-in of EGFR S492R mutation incis configuration with endogneous G719S mutationHeterozygous knock-in of EGFR mutation (T790M)conferring drug resistanceHeterozygous knock-in of EGFR mutation (T790M)conferring drug resistanceHomozygous knock-out of TP53; heterozygousknockin of EGFR activating mutation (ΔE746-A750/+)BRAFCDKN2ACTNNB1EGFRPIK3CAPIK3R1ATCCPIK3CAPIK3CAはp110α触媒サブユニットをコードしています。PI3KはPI3K/AKT/mTORパスウェイを介して、細胞の増殖や生存、移動、さらに小胞輸送を制御している事が知られています。また、PIK3CAの突然変異は、大腸がん、肺がん、卵巣がん、乳がん等に関与している事が知られています。遺伝子名カタログNo.細胞株名組織関連商品(+/del) HTB-119 NCI-H69 LungPhosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunitalpha(+/R88Q) HTB-114 SK-UT-1 Uterus TCP-1023、TCP-1024(+/R88Q) HTB-31 C-33 A Cervix TCP-1022PTENRASRB1SMAD4TP5321