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2013ATCC

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2013ATCC

123456789Horizon Discovery全細胞株リストAvailable Isogenic Cell Lines14-3-3σ(SFN)遺伝子名カタログNo.親株名組織特記事項SFN (-/-) HD R02-001 HCT116 Colon Homozygous knock-out of SFNABL (ABL1)ABL1 (T315I/+) HD 104-023 HCT116 ColonAKT1Heterozygous knock-in of ABL1 mutation (T315I)conferring drug resistanceAKT1 (-/-) HD R00-001 DLD-1 Colon Homozygous knock-out of AKT1AKT1 (-/-) HD R02-004 HCT116 Colon Homozygous knock-out of AKT1AKT1 (-/-); AKT2 (-/-) HD R00-003 DLD-1 Colon Double homozygous knock-out of AKT1 and AKT2AvailableIsogenic Cell LinesAKT1 (-/-); AKT2 (-/-) HD R02-006 HCT116 Colon Double homozygous knock-out of AKT1 and AKT2AKT1 (E17K/+) HD 101-007 MCF10A BreastAKT2Heterozygous knock-in of AKT1 PH domain activatingmutationAKT2 (-/-); AKT1 (-/-) HD R00-003 DLD-1 Colon Double homozygous knock-out of AKT1 and AKT2In DevelopmentIsogenic Cell LinesAvailableTagged and ReporterCell LinesIn DevelopmentTagged and ReporterCell LinesAvailableX-MAN ? NanoLuc ?Reporter KitsAvailableX-MAN ? HaloTag RReporter KitsAKT2 (-/-); AKT1 (-/-) HD R02-006 HCT116 Colon Double homozygous knock-out of AKT1 and AKT2AKT2 (-/-) HD R00-002 DLD-1 Colon Homozygous knock-out of AKT2AKT2 (-/-) HD R02-005 HCT116 Colon Homozygous knock-out of AKT2ALKALK (F1174L/+) HD 104-024 HCT116 ColonAPOC1Heterozygous knock-in of ALK activating mutation(F1174L)APOC1 (-/-) HD R02-007 HCT116 Colon Homozygous knock-out of APOC1ARID1AARID1A (Q456*/+) HD 104-031 HCT116 ColonARID1A (Q456*/Q456*) HD 104-049 HCT116 ColonArtemis (DCLRE1C)Heterozygous knock-out of ARID1A by knock-in ofpremature stop codon (Q456*)Homozygous knock-out of ARID1A by knock-in ofpremature stop codon (Q456*)DCLRE1C (-/-) HD 115-045 NALM-6 B-Cell Homozygous knock-out of DCLRE1CDCLRE1C (+/-) HD R10-001 hTERT RPE-1 RetinapigmentepitheliumATRATR (a2101g/+); TP53 (S241F/sil) HD R00-025 DLD-1 ColonATR (a2101g/a2101g); TP53 (+/sil) HD 202-001 DLD-1 ColonATR (a2101g/a2101g); TP53 (S241F/sil) HD 105-010 DLD-1 ColonATR (shRNA rescue/+) HD 106-012 RKO ColonHeterozygous knock-out of DCLRE1CHeterozygous hypomorphic ATR mutation (Seckel);TP53 mutant (S241F) backgroundHomozygous hypomorphic ATR mutation (Seckel);knock-in of wild type TP53Homozygous hypomorphic ATR mutation (Seckel);TP53 mutant (S241F) backgroundHeterozygous knock-in of ATR shRNA rescuesequence46