ブックタイトル2013ATCC

概要

2013ATCC

遺伝子名カタログNo.親株名組織特記事項PRKDC (-/-); PRKDC cDNA overexpression HD R02-050 HCT116 ColonPRKDC (-/-); XRCC6 (+/-) HD R02-051 HCT116 ColonHomozygous knock-out of endogenous PRKDC withoverexpression of wild type PRKDCHomozygous knock-out of PRKDC; heterozygousknock-out of XRCC6PRKDC (+/-) HD R02-048 HCT116 Colon Heterozygous knock-out of PRKDCPRKDC (+/-) HD R08-001 NALM-6 B-Cell Heterozygous knock-out of PRKDCPRKDC (+/-) HD R09-001 hTERT-BJ Skin Heterozygous knock-out of PRKDCPRKDC (+/-) HD R10-003 hTERT RPE-1 RetinapigmentepitheliumDNMT1DNMT1 (Δexons3-5/+) HD R02-021 HCT116 ColonHeterozygous knock-out of PRKDCHeterozygous knock-out of DNMT1 exons 3-5encoding PCNA binding domainHorizon Discovery全細胞株リスト123456789DNMT1 (Δexons3-5/+); DNMT3A (-/-);DNMT3B (-/-); CDKN 2A (R24fs*20/-)DNMT1 (Δexons3-5/+);DNMT3B (-/-);CDKN2A(R24fs*20/-)HD R02-027 HCT116 ColonHD R02-026 HCT116 ColonDNMT1 (Δexons3-5/Δexons3-5) HD R02-020 HCT116 ColonHeterozygous knock-out of DNMT1 exons 3-5;double homozygous knock-out of DNMT3A andDNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental cellsHeterozygous knock-out of DNMT1 exons 3-5;homozygous knock-out of DNMT3B; heterozygousknock-out of wild type CDKN2A allele in heterozygousHomozygous knock-out of DNMT1 exons 3-5encoding PCNA binding domainAvailableIsogenic Cell LinesDNMT1 (Δexons3-5/Δexons3-5);DNMT3B (-/-)DNMT1 (Δexons3-5/Δexons3-5);DNMT3B (-/-) retains CH3DNMT1 (Δexons3-5/Δexons3-5);DNMT3B (-/-); CDKN2A (R24fs*20/-)DNMT1 (Δexons3-5/Δexons3-5);DNMT3B (-/-); CDKN2A (sil/-)DNMT3a (DNMT3A)DNMT3A (-/-); DNMT1 (Δexons3-5/+);DNMT3B (-/-); CDKN 2A (R24fs*20/-)DNMT3b (DNMT3B)DNMT3B (-/-); DNMT1 (Δexons3-5/+);DNMT3A (-/-); CDKN 2A (R24fs*20/-)HD R02-022HCT116ColonHD R02-079HCT116ColonHD R02-024HCT116ColonHD R02-025HCT116ColonHD R02-027HCT116ColonHD R02-027HCT116ColonDouble homozygous knock-out of DNMT1 exons 3-5encoding PCNA binding domain and DNMT3BDouble homozygous knock-out of DNMT1 exons3-5 encoding PCNA binding domain and DNMT3B,retains methylationDouble homozygous knock-out of DNMT1 exons 3-5and DNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental cellsDouble homozygous knock-out of DNMT1 exons 3-5and DNMT3B; heterozygous knock-out of frameshiftmutant (R24fs*20) CDKN2A allele in heterozygousparental cellsHeterozygous knock-out of DNMT1 exons 3-5;double homozygous knock-out of DNMT3A andDNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental cellsHeterozygous knock-out of DNMT1 exons 3-5;double homozygous knock-out of DNMT3A andDNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental4 cellsIn DevelopmentIsogenic Cell LinesAvailableTagged and ReporterCell LinesIn DevelopmentTagged and ReporterCell LinesDNMT3b (DNMT3B)DNMT3B(-/-); DNMT1 (Δexons3-5/+);CDKN2A(R24fs*20/-)DNMT3B (-/-);DNMT1 (Δexons3-5/Δexons3-5)HD R02-026HCT116ColonHD R02-022HCT116ColonHeterozygous knock-out of DNMT1 exons 3-5;homozygous knock-out of DNMT3B; heterozygousknock-out of wild type CDKN2A allele in heterozygousDouble homozygous knock-out of DNMT1 exons 3-5encoding PCNA binding domain and DNMT3BAvailableX-MAN ? NanoLuc ?Reporter KitsDNMT3B (-/-) retains CH3;DNMT1 (Δexons3-5/Δexons3-5)DNMT3B (-/-);DNMT1 (Δexons3-5/Δexons3-5);CDKN2A (R24fs*20/-)HD R02-079HCT116ColonHD R02-024HCT116ColonDouble homozygous knock-out of DNMT1 exons3-5 encoding PCNA binding domain and DNMT3B,retains methylationDouble homozygous knock-out of DNMT1 exons 3-5and DNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental cellsAvailableX-MAN ? HaloTag RReporter Kits49