ブックタイトル2013ATCC

概要

2013ATCC

123456789Horizon Discovery全細胞株リスト遺伝子名カタログNo.親株名組織特記事項DNMT3B (-/-);DNMT1 (Δexons3-5/Δexons3-5);CDKN2A (sil/-)HD R02-025 HCT116 ColonDouble homozygous knock-out of DNMT1 exons 3-5and DNMT3B; heterozygous knock-out of frameshiftmutant (R24fs*20) CDKN2A allele in heterozygousparental cellsDNMT3B (-/-) HD R02-023 HCT116 Colon Homozygous knock-out of DNMT3BEGFREGFR (ΔE746-A750/+); BRAF (V600E/+) HD 200-002 hTERT-HME1 BreastEGFR (ΔE746-A750/+) HD 106-009 RKO ColonEGFR (ΔE746-A750/+) HD 114-004 NCI-H838 LungEGFR (ΔE746-A750/+) HD 100-001 hTERT-HME1 BreastDouble heterozygous knock-in of BRAF and EGFRactivating mutationsHeterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)Heterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)Heterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)EGFR (ΔE746-A750/+) HD 101-010 MCF10A BreastHeterozygous knock-in of EGFR activating mutation(ΔE746-A750/+)AvailableIsogenic Cell LinesEGFR (ΔE746-A750/+);PIK3CA (H1047R/+)EGFR (ΔE746-A750/+);PIK3CA (H1047R/+)HD 200-001 hTERT-HME1 BreastHD 201-001 MCF10A BreastDouble heterozygous knock-in of EGFR and PIK3CAactivating mutationsDouble heterozygous knock-in of EGFR and PIK3CAactivating mutationsIn DevelopmentIsogenic Cell LinesEGFR (I491M/+/+) HD 103-042 SW48 ColonHeterozygous knock-in of EGFR I491M mutation incis configuration with endogneous G719S mutationEGFR (L65V/+/+) HD 103-046 SW48 Colon Heterozygous knock-in of EGFR point mutation (L65V)EGFR (L858R/+) HD 106-006 RKO ColonEGFR (L858R/+) HD 114-005 NCI-H838 LungHeterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L858R)AvailableTagged and ReporterCell LinesIn DevelopmentTagged and ReporterCell LinesAvailableX-MAN ? NanoLuc ?Reporter KitsEGFR (L858R/+)HD 101-016MCF10ABreastEGFR (L858R/+/+)HD 103-045SW48ColonEGFR (L861Q/+)HD 106-007RKOColonEGFR (L861Q/+)HD 101-017MCF10ABreastEGFR (S492R/+/+)HD 103-041SW48ColonEGFR (S492R/+/+)HD 103-044SW48ColonEGFR (T790M/+)HD 106-005RKOColonEGFR (T790M/+)HD 101-019MCF10ABreastEGFR (ΔE746-A750/+); TP53 (-/-)HD 101-029MCF10ABreastFANCCFANCC (-/-/-)HD R05-006RKOColonHeterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L858R)Heterozygous knock-in of EGFR activating mutation(L861Q)Heterozygous knock-in of EGFR activating mutation(L861Q)Heterozygous knock-in of EGFR S492R mutation intrans configuration with endogneous G719S mutationHeterozygous knock-in of EGFR S492R mutation incis configuration with endogneous G719S mutationHeterozygous knock-in of EGFR mutation (T790M)conferring drug resistanceHeterozygous knock-in of EGFR mutation (T790M)conferring drug resistanceHomozygous knock-out of TP53; heterozygousknockin of EGFR activating mutation (ΔE746-A750/+)Knock-out of all three FANCC alleles in triploidparental cellsAvailableX-MAN ? HaloTag RReporter KitsFANCC (+/-/-) HD R05-004 RKO ColonFANCGKnock-out of two FANCC alleles in triploid parentalcellsFANCG (-/-) HD R05-005 RKO Colon Homozygous knock-out of FANCG50