ブックタイトル2013ATCC

概要

2013ATCC

123456789Horizon Discovery全細胞株リスト遺伝子名カタログNo.親株名組織特記事項NRAS (Q61R/+) HD 103-022 SW48 ColonNOTCH1NOTCH1 (L1601P/+) HD 104-027 HCT116 Colonp16INK4A (CDKN2A)CDKN2A (R24fs*20/-);DNMT1 (Δexons3-5/+);DNMT3A (-/-); DNMT3B (-/-)CDKN2A (R24fs*20/-);DNMT1 (Δexons3-5/+);DNMT3B (-/-)HD R02-027 HCT116 ColonHD R02-026 HCT116 ColonHeterozygous knock-in of NRAS activating mutation(Q61R)Heterozygous knock-in of NOTCH1 activatingmutation (L1601P)Heterozygous knock-out of DNMT1 exons 3-5;double homozygous knock-out of DNMT3A andDNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental cellsHeterozygous knock-out of DNMT1 exons 3-5;homozygous knock-out of DNMT3B; heterozygousknock-out of wild type CDKN2A allele in heterozygousAvailableIsogenic Cell LinesCDKN2A(R24fs*20/-);DNMT1 (Δexons3-5/Δexons3-5);DNMT3B (-/-)CDKN2A (sil/-);DNMT1 (Δexons3-5/Δexons3-5);DNMT3B (-/-)HD R02-024 HCT116 ColonHD R02-025 HCT116 ColonDouble homozygous knock-out of DNMT1 exons 3-5and DNMT3B; heterozygous knock-out of wild typeCDKN2A allele in heterozygous parental cellsDouble homozygous knock-out of DNMT1 exons 3-5and DNMT3B; heterozygous knock-out of frameshiftmutant (R24fs*20) CDKN2A allele in heterozygousparental cellsIn DevelopmentIsogenic Cell Linesp21 (CDKN1A)CDKN1A (-/-); BAX (-/-) HD R02-010 HCT116 Colon Double homozygous knock-out of BAX and CDKN1ACDKN1A (-/-); BBC3 (-/-) HD R02-041 HCT116 ColonDouble homozygous knock-out of CDKN1A andBBC3CDKN1A (-/-) HD R02-035 HCT116 Colon Homozygous knock-out of CDKN1AAvailableTagged and ReporterCell LinesIn DevelopmentTagged and ReporterCell LinesAvailableX-MAN ? NanoLuc ?Reporter KitsAvailableX-MAN ? HaloTag RReporter KitsCDKN1A (-/-) HD R00-020 DLD-1 Colon Homozygous knock-out of CDKN1Ap53 (TP53)TP53 (S241F/sil); ATR (a2101g/+) HD R00-025 DLD-1 ColonTP53 (+/sil); ATR (a2101g/a2101g) HD 202-001 DLD-1 ColonTP53 (S241F/sil); ATR (a2101g/a2101g) HD 105-010 DLD-1 ColonHeterozygous hypomorphic ATR mutation (Seckel);TP53 mutant (S241F) backgroundHomozygous hypomorphic ATR mutation (Seckel);knock-in of wild type TP53Homozygous hypomorphic ATR mutation (Seckel);TP53 mutant (S241F) backgroundTP53 (-/-); CDK2 (-/-) HD R02-016 HCT116 Colon Double homozygous knock-out of CDK2 and TP53TP53 (+/+); CHEK1 (+/-) HD R02-077 HCT116 ColonTP53 (+/sil); CHEK1 (+/-) HD R00-026 DLD-1 ColonTP53 (-/-); CHEK1 (+/-) HD R02-078 HCT116 ColonTP53 (S241F/sil); CHEK1 (S317A/-) HD R00-007 DLD-1 ColonTP53 (-/-); CHEK2 (-/-) HD R02-018 HCT116 ColonTP53 (+/+); CHEK2 (-/-) HD R02-017 HCT116 ColonHeterozygous knock-out of CHEK1; TP53 wild typebackgroundHeterozygous knock-out of CHEK1; knock-in of wildtype TP53Heterozygous knock-out of CHEK1; TP53 nullbackgroundHeterozygous knock-in of phosphorylation sitemutant and knock-out of wild type CHEK1; TP53(S241F) mutant backgroundHomozygous knock-out of CHEK2; TP53 nullbackgroundHomozygous knock-out of CHEK2; TP53 wild typebackgroundTP53 (-/-) HD 104-001 HCT116 Colon Homozygous knock-out of TP53TP53 (-/-) HD 106-002 RKO Colon Homozygous knock-out of TP5356