ブックタイトル2013ATCC

概要

2013ATCC

123456789Horizon Discovery全細胞株リスト遺伝子名カタログNo.親株名組織特記事項PIK3CA (H1047R/+); TP53 (-/-) HD 101-043 MCF10A BreastPIK3CA (+/-) HD 104-007 HCT116 ColonPIK3CA (+/-) HD 105-001 DLD-1 ColonPIK3CA (E542K/+) HD 103-016 SW48 ColonPIK3CA ( E545K/-) HD 105-012 DLD-1 ColonPIK3CA (E545K/+) HD 100-003 hTERT-HME1 BreastPIK3CA (E545K/+) HD 101-002 MCF10A BreastPIK3CA (E545K/+) HD 103-001 SW48 ColonHeterozygous knock-in of PIK3CA kinase domainactivating mutation in TP53 (-/-) parental cell lineKnock-out of PIK3CA kinase domain mutant allele(H1047R) in heterozygous parental cellsKnock-out of PIK3CA helix domain mutant allele(E545K) in heterozygous parental cellsHeterozygous knock-in of PIK3CA helix domainactivating mutationKnock-out of PIK3CA wild type allele in heterozygousparental cellsHeterozygous knock-in of PIK3CA helix domainactivating mutationHeterozygous knock-in of PIK3CA helix domainactivating mutationHeterozygous knock-in of PIK3CA helix domainactivating mutationAvailableIsogenic Cell LinesPIK3CA (H1047R/-)HD 104-012HCT116ColonPIK3CA (H1047R/+)HD 107-003VACO 432ColonPIK3CA (H1047R/+)HD 100-002hTERT-HME1BreastPIK3CA (H1047R/+)HD 101-011MCF10ABreastKnock-out of PIK3CA wild type allele in heterozygousparental cellsHeterozygous knock-in of PIK3CA kinase domainactivating mutationHeterozygous knock-in of PIK3CA kinase domainactivating mutationHeterozygous knock-in of PIK3CA kinase domainactivating mutationIn DevelopmentIsogenic Cell LinesAvailableTagged and ReporterCell LinesIn DevelopmentTagged and ReporterCell LinesAvailableX-MAN ? NanoLuc ?Reporter KitsAvailableX-MAN ? HaloTag RReporter KitsPIK3CA (H1047R/+) HD 103-005 SW48 ColonPIK3CA (H1047R/+); KRAS (G12V/+) HD 201-003 MCF10A BreastPIK3CA (H1047R/+/+/+) HD 127-001 WiDr ColonPPARδ(PPARD)Heterozygous knock-in of PIK3CA kinase domainactivating mutationDouble heterozygous knock-in of KRAS and PIK3CAactivating mutationsHeterozygous knock-in of PIK3CA kinase domainactivating mutationPPARD (-/-) HD R02-038 HCT116 Colon Homozygous knock-out of PPARDPTENPTEN (-/-) HD 104-004 HCT116 ColonPTEN (-/-) HD 101-006 MCF10A BreastPTEN (+/-) HD 104-057 HCT116 ColonPTEN (R130*/R130*) HD 103-012 SW48 ColonPUMA (BBC3)Homozygous knock-out of PTEN by deletion of exon5 which encodes active site of proteinHomozygous knock-out of PTEN by deletion of exon2 resulting in a frameshiftHeterozygous knock-out of PTEN by deletion ofexons 6 and 7Homozygous knock-out of PTEN by knock-in ofpremature stop codon (R130*)BBC3 (-/-) HD R02-040 HCT116 Colon Homozygous knock-out of BBC3BBC3 (-/-) HD R00-029 DLD-1 Colon Homozygous knock-out of BBC3BBC3 (-/-); CDKN1A (-/-) HD R02-041 HCT116 ColonBBC3 (ΔTP53BS/ΔTP53BS) HD R02-098 HCT116 ColonBBC3 (ΔTP53BS/ΔTP53BS) HD R00-042 DLD-1 ColonRac1 (RAC1)Double homozygous knock-out of CDKN1A andBBC3Homozygous knock-out of TP53 binding site in BBC3promoterHomozygous knock-out of TP53 binding site in BBC3promoterRAC1 (Q61L/+) HD 101-014 MCF10A Breast Heterozygous knock-in of RAC1 mutant (Q61L)58